Position located in Boston, MA
Responsibilities of the Director of Computational Biology and AI/ML Platform:
Will lead the development and implementation of our computational infrastructure for antibody discovery and optimization.Design and implement the computational platform architecture for antibody discovery, integrating ML/DL models, structural biology tools, and high-throughput screening data analysis into the pipelineDevelop and deploy ML models for antibody-antigen binding prediction, affinity maturation, and developability assessmentDevelop state-of-the-art deep learning models for structure-based antibody design, antibody sequence design, antibody-antigen co-folding, and antibody-antigen binding predictionLead the integration of AlphaFold, Rosetta Antibody/Rosetta Fold, Boltz-1, and other state-of-the-art protein structure prediction tools into the discovery pipelineCreate and maintain computational workflows for analyzing large-scale screening data (phage display, yeast display, NGS data) to identify lead candidatesPartner with teammates in Platform Engineering and Discovery to identify key challenges and design innovative, AI-driven solutions using in silico and in vitro validation resultsImplement structural modeling pipelines including homology modeling, molecular dynamics simulations, and protein-protein docking for antibody optimizationUse expertise to influence the Founding and research team’s agenda while maintaining a high level of responsibility and accountability for work deliverables Requirements of the Director of Computational Biology and AI/ML Platform:
PhD in Computational Biology, Bioinformatics, Computer Science, Physics, or related quantitative field with 5+ years of industry experience in biologics/antibody discoveryProven expertise in machine learning and deep learning frameworks (PyTorch, TensorFlow, JAX) and state-of the-art AI algorithms applied to protein design and structure predictionStrong background in protein, molecular dynamics, and antibody-specific computational tools and databases (IMGT, AbNum, Chothia numbering, etc.)Skilled in high-throughput data analysis (NGS, display technologies) and structural biologysoftware (PyMOL, Rosetta, Schrödinger suite, MOE)Proficiency in Python, with experience in R, C++, or Julia as a plusKnowledge of antibody biology and therapeutic antibody development process is a plus.