Principal Scientist, Single Cell & Spatial Proteomics

Job description

At Johnson & Johnson, we believe health is everything.

Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

Learn more at https://www.jnj.com

**Job Function:**

Discovery & Pre-Clinical/Clinical Development

**Job Sub** **Function:**

Biological Research

**Job Category:**

Scientific/Technology

**All Job Posting Locations:**

Cambridge, Massachusetts, United States of America

**Job Description:**

Johnson & Johnson Innovative Medicine is recruiting for a Principal Scientist, Proteomics for our site in Cambridge, MA.

**About Innovative Medicine:**

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.

Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

**Learn more at https://www.jnj.com/innovative-medicine**

Do you want to use your hard-earned skills and drive to make a difference in the lives of patients?

This candidate will join the growing Discovery Proteomic Platforms (DPP) group within the Multiomics Discovery Team to:

+ Apply groundbreaking approaches to proteomic analysis at multiple resolutions, from bulk to single cell and spatial
+ Build new platforms to help drive insights in target identification, target validation, and therapeutic optimization
+ Be a part of a motivated team dedicated to deploying groundbreaking technologies to support the identification and development of small and large molecule therapeutics for diseases within Oncology, Immunology, and Neuroscience
+ Work in an exciting, interdisciplinary environment, overlapping the different stages of the discovery pipeline

**You will be responsible to:**

+ Drive the build of novel platforms for the analysis of single cell and spatial proteomics samples working with colleagues with expertise in data infrastructure, bioinformatics, and biostatistics
+ Join a team of wet lab scientists enabling proteomic insights across a wide variety of programs and therapeutic modalities.
+ Plan and perform wet lab proteomic activities related to target engagement/deconvolution/identification, therapeutic optimization, and interactome networking.
+ Work hands on with our fleet of next generation LC-MS systems maintaining, building, and deploying high throughput methodologies to drive program and target insights.
+ Present data and reports on project status at individual, working group, and project meeting settings.
+ Demonstrate creativity and apply novel approaches to solving scientific problems.

Propose novel and practical ideas, aligned with scientific strategies and demands.

**Qualifications**

**Education:**

+ A Doctoral degree (in Chemistry, Biochemistry, Chemical Biology, Molecular Biology, Pharmacology, or a related field) is required.

**Experience and Skills:**

**Required:**

+ 3 years of proven experience in an industrial mass spectrometry lab setting is required.
+ Experience maintaining and deploying liquid chromatography (Vanquish Neo or Evosep One) and mass spectrometry (Bruker timsTOF, Thermo Tribrid) instrumentation is required.
+ Experience processing and analyzing large scale proteomic datasets is required.
+ Strong planning and project coordination skills with the ability to handle several projects at a time in a fast-paced environment is required.
+ Excellent interpersonal skills working to enable working on a multidisciplinary team is required.
+ Experience using single cell or spatial proteomics is required.

**Preferred:**

+ Experience in a pharmaceutical setting is preferred.
+ Experience using the Thermo Astral and Evosep is preferred.
+ Proficiency with lab liquid handling automation (AssayMAP Bravo, Beckman Biomek, Hamilton Microlab STAR, TECAN Fluent, Dynamic Devices Lynx) use is preferred.
+ Proficiency in microscopy for spatial proteomics or single cell handling platforms (Cellenone, Uno) is preferred.

The anticipated base pay range for this position is $115,000 - $197,800.

The Company maintains highly competitive, performance-based compensation programs.

Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan.

The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year.

Bonuses are awarded at the Company’s discretion on an individual basis.

Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

+ This position is eligible to participate in the Company’s long-term incentive program.

**Employees are eligible for the following time off benefits:**

+ Vacation – up to 120 hours per calendar year
+ Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year
+ Holiday pay, including Floating Holidays – up to 13 days per calendar year
+ Work, Personal and Family Time - up to 40 hours per calendar year

Additional information can be found through the link below.

For additional general information on Company benefits, please go to:

+ https://www.careers.jnj.com/employee-benefits

Johnson & Johnson is an Equal Opportunity Employer.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law.

We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs.

If you are an individual with a disability and would like to request an accommodation, please contact us via https://www.jnj.com/contact-us/careers or contact AskGS to be directed to your accommodation resource.

**The anticipated base pay range for this position is :**

$115,000 - $197,800

Additional Description for Pay Transparency:

Required Skill Profession

Other General