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Senior Scientist, Cancer Vaccine and Bioinformatics Research Job Opening In Cambridge – Now Hiring Moderna


Job description

The Role
Moderna is seeking a Senior Scientist to join a highly collaborative, multi-disciplinary, fast-paced Cancer Vaccine and Bioinformatics Research (CVBR) team based in Cambridge, MA.

You will evaluate cancer-specific genomic aberrations and immune-evasion mechanisms, and translate public and proprietary datasets into high-value training data to develop and validate bioinformatics algorithms for individualized neoantigen therapy (INT).

You will partner closely with computational biologists, immunologists, translational scientists, clinicians, and machine-learning scientists to drive INT discovery and clinical development.

Here’s What You’ll Do

  • Lead the end-to-end cancer genomics analytics strategy to surface clinically and biologically meaningful variants and events.

  • Set and enforce best practices and quality standards for detection and interpretation across assays.

  • Match sequencing and library modalities to study goals to maximize signal, cost-effectiveness, and turnaround.

  • Develop, validate, and operationalize core algorithms and QC for the INT workflow.

  • Integrate multi-omics data to cross-validate findings and prioritize actionable neoantigens.

  • Build scalable, reproducible pipelines using workflow managers (e.g.,Nextflow) and containerization

  • Collaborate with discovery and translational biology to shape experimental designs, data generation plans, and sample selection; contribute to clinical protocols, data review, and regulatory-grade documentation.

  • Communicate results and recommendations clearly to diverse stakeholders; mentor junior scientists and help grow team capabilities.

Here’s What You’ll Need (Basic Qualifications)

  • Ph.D. in Bioinformatics, Computational Biology, Computer Science, Statistics, Physics, or related field with at least two years post graduate experience in relevant bioinformatics research settings, preferrable in biotech industry.

  • Demonstrated track record developing genomics data-analysis algorithms and delivering production-quality tools.

  • Proficiency in Python, R, Nextflow, high-performance and cloud computing (e.g., AWS).

Here’s What You’ll Bring to the Table (Preferred Qualifications)

  • Expertise with workflow systems (Nextflow preferred; Snakemake, Cromwell) and containerization (Docker); familiarity with software best practices (version control, code review, testing).

  • Experience mining and harmonizing large-scale resources (TCGA, GTEx, CCLE, IMGT, 1000G, ExAC/gnomAD).

  • Depth in algorithm evaluation, machine learning, and domain expertise in oncology

  • Hands-on experience with somatic mutation detection, fusion/splicing detection, long-read RNA-seq (PacBio HiFi/Iso-Seq; ONT cDNA/direct RNA), and SV calling

  • Strong problem-solving skills, clear written and verbal communication, and the ability to manage multiple projects in a dynamic, cross-functional environment.

At Moderna, we believe that when you feel your best, you can do your best work.  That’s why our US benefits and global well-being resources are designed to support you—at work, at home, and everywhere in between.

  • Best-in-class healthcare coverage, plus a suite of voluntary benefit programs to support your unique needs
  • A holistic approach to well-being, with access to fitness, mindfulness, and mental health support
  • Lifestyle Spending Accounts to personalize your well-being journey
  • Family planning and adoption benefits
  • Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown
  • Savings and investment opportunities
  • Location-specific perks and extras

Required Skill Profession

Life Scientists


  • Job Details

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Unlock Your Senior Scientist Potential: Insight & Career Growth Guide


Real-time Senior Scientist Jobs Trends (Graphical Representation)

Explore profound insights with Expertini's real-time, in-depth analysis, showcased through the graph here. Uncover the dynamic job market trends for Senior Scientist in Cambridge, United States, highlighting market share and opportunities for professionals in Senior Scientist roles.

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The Work Culture

An organization's rules and standards set how people should be treated in the office and how different situations should be handled. The work culture at Moderna adheres to the cultural norms as outlined by Expertini.

The fundamental ethical values are:

1. Independence

2. Loyalty

3. Impartiapty

4. Integrity

5. Accountabipty

6. Respect for human rights

7. Obeying United States laws and regulations

What Is the Average Salary Range for Senior Scientist, Cancer Vaccine and Bioinformatics Research Positions?

The average salary range for a varies, but the pay scale is rated "Standard" in Cambridge. Salary levels may vary depending on your industry, experience, and skills. It's essential to research and negotiate effectively. We advise reading the full job specification before proceeding with the application to understand the salary package.

What Are the Key Qualifications for Senior Scientist, Cancer Vaccine and Bioinformatics Research?

Key qualifications for Senior Scientist, Cancer Vaccine and Bioinformatics Research typically include Life Scientists and a list of qualifications and expertise as mentioned in the job specification. The generic skills are mostly outlined by the . Be sure to check the specific job listing for detailed requirements and qualifications.

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Interview Tips for Senior Scientist, Cancer Vaccine and Bioinformatics Research Job Success

Moderna interview tips for Senior Scientist, Cancer Vaccine and Bioinformatics Research

Here are some tips to help you prepare for and ace your Senior Scientist, Cancer Vaccine and Bioinformatics Research job interview:

Before the Interview:

Research: Learn about the Moderna's mission, values, products, and the specific job requirements and get further information about

Other Openings

Practice: Prepare answers to common interview questions and rehearse using the STAR method (Situation, Task, Action, Result) to showcase your skills and experiences.

Dress Professionally: Choose attire appropriate for the company culture.

Prepare Questions: Show your interest by having thoughtful questions for the interviewer.

Plan Your Commute: Allow ample time to arrive on time and avoid feeling rushed.

During the Interview:

Be Punctual: Arrive on time to demonstrate professionalism and respect.

Make a Great First Impression: Greet the interviewer with a handshake, smile, and eye contact.

Confidence and Enthusiasm: Project a positive attitude and show your genuine interest in the opportunity.

Answer Thoughtfully: Listen carefully, take a moment to formulate clear and concise responses. Highlight relevant skills and experiences using the STAR method.

Ask Prepared Questions: Demonstrate curiosity and engagement with the role and company.

Follow Up: Send a thank-you email to the interviewer within 24 hours.

Additional Tips:

Be Yourself: Let your personality shine through while maintaining professionalism.

Be Honest: Don't exaggerate your skills or experience.

Be Positive: Focus on your strengths and accomplishments.

Body Language: Maintain good posture, avoid fidgeting, and make eye contact.

Turn Off Phone: Avoid distractions during the interview.

Final Thought:

To prepare for your Senior Scientist, Cancer Vaccine and Bioinformatics Research interview at Moderna, research the company, understand the job requirements, and practice common interview questions.

Highlight your leadership skills, achievements, and strategic thinking abilities. Be prepared to discuss your experience with HR, including your approach to meeting targets as a team player. Additionally, review the Moderna's products or services and be prepared to discuss how you can contribute to their success.

By following these tips, you can increase your chances of making a positive impression and landing the job!

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